WebDifferential pharmacology and clinical utility of rolapitant in chemotherapy-induced nausea and vomiting Bernardo Leon Rapoport The Medical Oncology Centre of Rosebank, Johannesburg, South Africa Abstract: Chemotherapy-induced nausea and vomiting (CINV) is a debilitating side effect of many cytotoxic chemotherapy regimens. CINV typically … WebIn breast cancer patients who were enrolled in the phase 3 trial of rolapitant for CINV induced by MEC or AC-based regimens, 50 complete response rates were greater with rolapitant than with active control in the overall (62.8% vs 55.1%; P=0.023) and delayed phases (66.7% vs 59.8%; P=0.039) , as were no emesis rates, although no significant …

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