Putative polyketide synthase
WebModular polyketide synthases (PKSs) are polymerases that employ α-carboxyacyl-CoAs as extender substrates. This enzyme family contains several catalytic modules, where each … WebJun 26, 2024 · A putative biosynthetic pathway for HLM A, featuring a nonaketide-specific type II polyketide synthase, was proposed. It would be consistent with the isolation of HLM B and C, which are two new natural products and likely shunt metabolites during HLM A …
Putative polyketide synthase
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WebModular polyketide synthases (PKSs) are polymerases that employ α-carboxyacyl-CoAs as extender substrates. This enzyme family contains several catalytic modules, where each module is responsible for a single round of polyketide chain extension. Although PKS modules typically use malonyl-CoA or methylmalonyl-CoA for chain elongation, many … WebJul 18, 2024 · Usnic acid is a unique polyketide produced by lichens. To characterize usnic acid biosynthesis, the transcriptome of the usnic-acid-producing lichen-forming fungus …
WebDec 1, 2024 · We identified a non-reducing polyketide synthase candidate from P. furfuracea (PFUR17_02294) that showed close homology to the putative grayanic acid NR PKS, CgrPKS16 (Calchera et al., 2024). The protein sequence of the PFUR17_02294 ( Fig. S1 ) was deduced from genomic DNA contig PRJNA393286 and transcriptomic sequence data. WebAug 13, 2010 · Despite the unique phenotypic properties and clinical importance of Penicillium marneffei, the polyketide synthase genes in its genome have never been characterized.Twenty-three putative polyketide synthase genes and two putative polyketide synthase nonribosomal peptide-synthase hybrid genes were identified in the P. marneffei …
WebFeb 23, 2012 · They are synthesized from acyl-coenzyme A substrates by polyketide synthases (... IUBMB Life is the ... CoA, coenzyme A; PKS, polyketide synthase; FAS, fatty acid synthase; CHS, chalcone synthase ... The crystal structure of BAS also indicated the presence of a putative nucleophilic water molecule that forms hydrogen bond ... WebJun 25, 2010 · The oxazolomycin biosynthetic gene cluster (ozm) was identified from Streptomyces albus JA3453 and localized to 79.5-kb DNA, consisting of 20 open reading frames that encode non-ribosomal peptide synthases, polyketide synthases (PKSs), hybrid non-ribosomal peptide synthase-PKS, trans-acyltransferases (trans-ATs), enzymes for …
WebA putative biosynthetic pathway for HLM A, featuring a nonaketide-specific type II polyketide synthase, was proposed. It would be consistent with the isolation of HLM B
WebDec 3, 2024 · a In the bikaverin biosynthetic pathway, the polyketide synthase Bik1, activated by phosphopantetheinyl transferase (PPTase), condenses one acetyl-CoA and eight malonyl-CoA units to form pre ... boiling wineWebPolyketide synthase type-I 59 (type-I PKS) can provide linear products such as 71 with E,E-conjugated polyene system and E-enone system, which are reactive substrates for [4 + 2] … boiling wine for woundsWebSep 13, 2024 · We previously reported that chaetoglobosin A (ChA) exhibits a great potential in the biocontrol of nematodes and pathogenic fungi. To improve the production of ChA, a CRISPR-Cas9 system was created and applied for eliminating potential competitive polyketide products. One of the polyketide synthase encoding genes, Cgpks11, which is … boiling with rage ne demekWebThe genome of P. marneffei contains 23 putative polyketide synthase (PKS) genes and 2 putative PKS-nonribosomal peptide synthase hybrid genes . The citrinin PKS C6.123 gene was also discovered in the genome [ 90 ], opening the door for research into nonmycotoxin-producing strains if the citrinin gene can be suppressed without affecting the strain’s … boiling whole sweet potatoesWebSep 1, 2004 · ACE1 was isolated by map-based cloning and encodes a putative hybrid between a polyketide synthase and a nonribosomal peptide synthetase, enzymes involved … boiling wings before grillingWebLovastatin biosynthesis in Aspergillus terreus involves two unusual type I multifunctional polyketide syntheses (PKSs). Lovastatin nonaketide synthase (LNKS), the product of the lovB gene, is an iterative PKS that interacts with LovC, a putative enoyl reductase, to catalyze the 35 separate reactions in the biosynthesis of dihydromonacolin L, a lovastatin … boiling witch potWebPutative Monofunctional Type I Polyketide Synthase Units: A Dinoflagellate-Specific Feature? Karsten Eichholz, Ba´nk Beszteri, Uwe John* Alfred Wegener Institute for Polar … boiling whole sweet potatoes time