WebFeb 1, 2009 · The linear peptide derived from opening of the lactone ring was devoid of antifungal activity as well as toxicity. Phomafungin has been identified in a number of … WebApr 21, 2024 · Phomafungin is a recently reported broad spectrum antifungal compound but its biosynthetic pathway is unknown.
Isolation, structure and biological activity of phomafungin, a cyclic ...
WebNov 20, 2024 · Phoma is an exceptionally polyphyletic genus of rapidly growing soil fungi under the phylum of Ascomycota. The genus of Phoma includes more than 2000 species observed as phytopathogen or endophytes. The endophytic Phoma spp. have been isolated from a range of tropical/subtropical plants, arid climate of mangrove, mountain, desert, … WebMar 22, 2013 · Phaeofungin (1), a new cyclic depsipeptide isolated from Phaeosphaeria sp., was discovered by application of reverse genetics technology, using the Candida albicans fitness test (CaFT). Phaeofungin is comprised of seven amino acids and a β,γ-dihydroxy-γ-methylhexadecanoic acid arranged in a 25-membered cyclic depsipeptide. cytoflex flow cell
Isolation, structure and biological activity of phomafungin, …
WebThe preferred initial dosage in fungal keratitis is one drop of Pimafucin® (natamycin ophthalmic suspension) 5% instilled in the conjunctival sac at hourly or two-hourly … Weba lipodepsipeptide isolated from a Phaeosphaeria sp. using the C. albicans fitness test [7], or phomafungin, isolated from a Phoma sp. using the same approach [8]. The latter two compounds share a strong structural resemblance with compound 1 and phomafungin even shares the same 3-hydroxy-4-methylhexadecanoic acid structural unit. WebMay 14, 2024 · Background: Phomafungin is a recently reported broad spectrum antifungal compound but its biosynthetic pathway is unknown. We combed publicly available Phoma … cytoflex facs